Since I don't always have a ton of extra money to donate over the holidays, and I know many others are in the same boat, last year I held a small-scale online charity drive to collect money to buy items for children in Akron Children's Hospital via Child's Play Charity. I'm holding another this year.
It's a pretty simple set-up: Child's Play has already arranged for each hospital, including Akron, to create a wishlist for desired items on Amazon. You can buy items though Amazon and the items will be shipped directly to the hospital. My goal in banding a group of us together is that we can together buy some of the more expensive items for the children that we couldn't as individuals.
There's a PayPal donation button at the page, along with instructions for other donation methods, and a running total of how much we've collected. I'll also soon set up a poll so those who donate can vote on which items from the wishlist we buy. I've also created a Facebook group to help spread the word. Please check it out and pitch in if you're interested at www.deliberatepixel.com/cpc/.